Article
Stabilization of Xist RNA mediates initiation of X chromosome inactivation.
Cell - 3 Oct 1997
Sheardown S A, Duthie S M, Johnston C M, Newall A E, Formstone E J, Arkell R M, Nesterova T B, Alghisi G C, Rastan S, Brockdorff N
Abstract excerpt
The onset of X inactivation is preceded by a marked increase in the level of Xist RNA. Here we demonstrate that increased stability of Xist RNA is the primary determinant of developmental up-regulation. Unstable transcript is produced by both alleles in XX ES cells and in XX embryos prior to the onset of random X inactivation. Following differentiation, transcription of unstable RNA from the active X chromosome...
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