Article
Stabilization of Xist RNA mediates initiation of X chromosome inactivation.
Cell - 3 Oct 1997
Sheardown S A, Duthie S M, Johnston C M, Newall A E, Formstone E J, Arkell R M, Nesterova T B, Alghisi G C, Rastan S, Brockdorff N
Abstract excerpt
The onset of X inactivation is preceded by a marked increase in the level of Xist RNA. Here we demonstrate that increased stability of Xist RNA is the primary determinant of developmental up-regulation. Unstable transcript is produced by both alleles in XX ES cells and in XX embryos prior to the...
Topics
- Alleles
- Animals
- Blastocyst
- Cell Differentiation
- Cells, Cultured
- Dactinomycin
- Dosage Compensation, Genetic
- Female
- Gene Expression Regulation
- Male
- Mice
- Models, Genetic
- Nucleic Acid Synthesis Inhibitors
- RNA, Long Noncoding
- RNA, Messenger
- RNA, Untranslated
- Stem Cells
- Transcription Factors