Article
No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene.
Biological psychiatry - 15 Aug 1997
Kunugi H, Vallada H P, Hoda F, Kirov G, Gill M, Aitchison K J, Ball D, Arranz M J, Murray R M, Collier D A
Abstract excerpt
Catechol-o-methyltransferase (COMT) is an enzyme that inactivates biologically active or toxic catechols. Previous studies have yielded inconsistent results on the relationship between erythrocyte COMT activity and affective disorders. Recently an amino acid change (Val-108-Met) of the COMT protein was shown to determine high- and low-activity alleles of the enzyme. Using polymerase chain reaction and the...
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