Article
Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder.
Molecular psychiatry - 1 Jul 1998
Kirov G, Murphy K C, Arranz M J, Jones I, McCandles F, Kunugi H, Murray R M, McGuffin P, Collier D A, Owen M J, Craddock N
Abstract excerpt
Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines. An amino acid polymorphism (val-108-met) determines high and low activity of the enzyme. A recent study in a small sample of patients with velo-cardio-facial syndrome who had bipolar affective disorder sugg...
Topics
- Alleles
- Amino Acid Substitution
- Bipolar Disorder
- Catechol O-Methyltransferase
- Female
- Humans
- Male
- Middle Aged
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Risk Assessment
- United Kingdom
- White People