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Article

Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder.

Molecular psychiatry - 1 Jul 1998

Kirov G, Murphy K C, Arranz M J, Jones I, McCandles F, Kunugi H, Murray R M, McGuffin P, Collier D A, Owen M J, Craddock N

Abstract excerpt

Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines. An amino acid polymorphism (val-108-met) determines high and low activity of the enzyme. A recent study in a small sample of patients with velo-cardio-facial syndrome who had bipolar affective disorder suggested that the Met (low activity) COMT allele might be associated with rapid-cycling in this population. We therefore...

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Source

Identifiers

PMID: 9702744
DOI: 10.1038/sj.mp.4000385

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder.PMID 9702744Read ↗

Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele.Semantic proximity Read ↗

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Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder.Semantic proximity Read ↗

Ethnic differences in catechol O-methyltransferase pharmacogenetics: frequency of the codon 108/158 low activity allele is lower in Kenyan than Caucasian or South-west Asian individuals.Semantic proximity Read ↗

Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene.Semantic proximity Read ↗

No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group.Semantic proximity Read ↗

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndromeSemantic proximity Read ↗

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Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.Semantic proximity Read ↗

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