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Article

Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder.

Psychiatric genetics - 1 Jan 1997

Lachman H M, Kelsoe J, Moreno L, Katz S, Papolos D F

Abstract excerpt

Abnormal catecholamine transmission has been implicated in the pathogenesis of mood disorders. Consequently, alterations in genes that are involved in catecholamine metabolism could be potential candidates for bipolar affective disorder (BPD) vulnerability. One such candidate is catechol-O-methyltransferase (COMT). A functional polymorphism has recently been characterized that is responsible for substantial...

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Identifiers

PMID: 9264133
DOI: 10.1097/00041444-199700710-00002

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder.PMID 9264133Read ↗

Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder.Semantic proximity Read ↗

No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene.Semantic proximity Read ↗

No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder.Semantic proximity Read ↗

Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholismSemantic proximity Read ↗

Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior.Semantic proximity Read ↗

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.Semantic proximity Read ↗

Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.Semantic proximity Read ↗

Lack of association of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia.Semantic proximity Read ↗

Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study.Semantic proximity Read ↗

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndromeSemantic proximity Read ↗

Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression.Semantic proximity Read ↗

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