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Article

Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder.

The American journal of psychiatry - 1 Jan 1997

Gutiérrez B, Bertranpetit J, Guillamat R, Vallès V, Arranz M J, Kerwin R, Fañanás L

Abstract excerpt

OBJECTIVE: Catechol O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Two common COMT alleles determine high and low activity of the enzyme. Previous studies using biochemical methods found lower enzyme activity in patients with major depression and bipolar disorder in comp...

Topics

Alleles
Biomarkers
Bipolar Disorder
Catechol O-Methyltransferase
Female
Gene Frequency
Genetic Variation
Genotype
Humans
Male
Mutation
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Source

Identifiers

PMID: 8988970
DOI: 10.1176/ajp.154.1.113

Genes

COMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8988970-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder.PMID 8988970Read ↗

No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group.Semantic proximity Read ↗

Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder.Semantic proximity Read ↗

Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression.Semantic proximity Read ↗

No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene.Semantic proximity Read ↗

Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder.Semantic proximity Read ↗

Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) pharmacogenetics in the treatment response phenotypes of major depressive disorder (MDD).Semantic proximity Read ↗

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.Semantic proximity Read ↗

Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.Semantic proximity Read ↗

No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity.Semantic proximity Read ↗

Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes.Semantic proximity Read ↗

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