Article
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder.
Pharmacogenetics - 1 Oct 1997
Li T, Vallada H, Curtis D, Arranz M, Xu K, Cai G, Deng H, Liu J, Murray R, Liu X, Collier D A
Abstract excerpt
Catechol-O-methyltransferase catalyses the O-methylation of biologically active or toxic catechols and is a major component of the metabolism of drugs and neurotransmitters such as L-dopa, noradrenaline, adrenaline, and dopamine. Human catechol-O-methyltransferase activity is an autosomal partial...
Topics
- Bipolar Disorder
- Catechol O-Methyltransferase
- China
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Methionine
- Point Mutation
- Polymorphism, Genetic
- Valine