Article
Mutations, tissue accumulations, and serum levels of p53 in patients with occupational cancers from asbestos and silica exposure.
Environmental and molecular mutagenesis - 1 Jan 1997
Husgafvel-Pursiainen K, Kannio A, Oksa P, Suitiala T, Koskinen H, Partanen R, Hemminki K, Smith S, Rosenstock-Leibu R, Brandt-Rauf P W
Abstract excerpt
In order to determine the relationship between mutations, tissue accumulations, and serum levels of p53 in occupational cancers, we used denaturing gradient gel electrophoresis and DNA sequencing of exons 5-9 of the p53 gene, immunohistochemical analysis for tissue identification of mutant p53 protein, and enzyme-linked immunosorbent assay for serum levels of mutant p53 protein to examine for such alteration in a...
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