Article
Mutations of p53 gene and SV40 sequences in asbestos associated and non-asbestos-associated mesotheliomas.
Journal of clinical pathology - 1 Apr 1999
Mayall F G, Jacobson G, Wilkins R
Abstract excerpt
AIM: To examine mesotheliomas for a possible relation between p53 immunostaining, p53 gene mutation, simian virus 40 (SV40), and asbestos exposure. METHODS: Paraffin sections from 11 mesotheliomas were used for p53 immunostaining and also to extract DNA. This was analysed for the presence of mutations in exons 5 to 8 of the p53 gene using a "cold" single strand conformational polymorphism method, together with...
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