Article
Quantitative detection of p53 mutations in plasma DNA from tobacco smokers.
Cancer research - 15 Aug 2006
Hagiwara Nobutoshi, Mechanic Leah E, Trivers Glenwood E, Cawley Helen L, Taga Masataka, Bowman Elise D, Kumamoto Kensuke, He Peijun, Bernard Mark, Doja Saira, Miyashita Masao, Tajiri Takashi, Sasajima Koji, Nomura Tsutomu, Makino Hiroshi, Takahashi Ken, Hussain S Perwez, Harris Curtis C
Abstract excerpt
In lung tumors, the p53 tumor suppressor gene is commonly mutated with a characteristic mutation spectrum. The amount of and alterations in plasma DNA, such as mutations in p53, were associated with several cancers. Few studies used quantitative methods of high sensitivity. Previously, we observed p53 mutations in the noncancerous tissue that differed from those in lung tumors using the highly sensitive p53...
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