Article
Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations.
American journal of respiratory cell and molecular biology - 1 Apr 1999
Husgafvel-Pursiainen K, Karjalainen A, Kannio A, Anttila S, Partanen T, Ojajärvi A, Vainio H
Abstract excerpt
Studies on somatic mutations in lung cancers associated with cigarette smoking and asbestos exposure are few. We investigated prevalence of mutations in the p53 and K-ras genes in lung tumors from smokers with and without asbestos exposure at work. For K-ras mutations, the study was an extension of an earlier analysis. Nearly all of the 105 consecutive patients examined were smokers and had non-small-cell...
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