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Mutations in the p53 gene in lung cancer are associated with cigarette smoking and asbestos exposure.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000

Wang X, Christiani D C, Wiencke J K, Fischbein M, Xu X, Cheng T J, Mark E, Wain J C, Kelsey K T

Abstract excerpt

It has been proposed that the patterns of mutations in the p53 tumor suppressor gene will provide clues to the mechanisms of cancer occurrence. Cigarette smoking is known to be the greatest risk factor for lung cancer. Epidemiological evidence has also implicated radon and asbestos as exposures that significantly increase this disease risk; asbestos exposure synergistically enhances the lung cancer risk of...

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PMID: 7549812

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