Article
Laboratory probing of oncogenes from human liquid and solid specimens as markers of exposure to toxicants.
Critical reviews in toxicology - 1 Sept 1996
Nelson E
Abstract excerpt
Recent discoveries regarding the mechanistic role of oncogenes and tumor suppressor genes in cancer development have opened a new era of molecular diagnosis. It has been observed repeatedly that genetic lesions serve as tumor markers in a broad variety of human cancers. The ras gene family, consisting of three related genes, H-ras, K-ras, and N-ras, acquires transforming activity through amplification or mutation...
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