Article
Laboratory probing of oncogenes from human liquid and solid specimens as markers of exposure to toxicants.
Critical reviews in toxicology - 1 Sept 1996
Nelson E
Abstract excerpt
Recent discoveries regarding the mechanistic role of oncogenes and tumor suppressor genes in cancer development have opened a new era of molecular diagnosis. It has been observed repeatedly that genetic lesions serve as tumor markers in a broad variety of human cancers. The ras gene family, consi...
Topics
- Biomarkers
- Biomarkers, Tumor
- Disease Models, Animal
- Flow Cytometry
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genes, ras
- Genetic Predisposition to Disease
- Humans
- Immunoblotting
- Immunohistochemistry
- Mutation
- Neoplasms
- Occupational Exposure
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins
- Tumor Cells, Cultured
