Differential mutation profiles and similar intronic TP53 polymorphisms in asbestos-related lung cancer and pleural mesothelioma.

doi:10.1093/mutage/get008

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Differential mutation profiles and similar intronic TP53 polymorphisms in asbestos-related lung cancer and pleural mesothelioma.

Mutagenesis - 1 May 2013

Andujar Pascal, Pairon Jean-Claude, Renier Annie, Descatha Alexis, Hysi Ilir, Abd-Alsamad Issam, Billon-Galland Marie-Annick, Blons Hélène, Clin Bénédicte, Danel Claire, Debrosse Denis, Galateau-Sallé Françoise, Housset Bruno, Laurent-Puig Pierre, Le Pimpec-Barthes Françoise, Letourneux Marc, Monnet Isabelle, Régnard Jean-François, Validire Pierre, Zucman-Rossi Jessica, Jaurand Marie-Claude, Jean Didier

Abstract excerpt

Given the interest in defining biomarkers of asbestos exposure and to provide insights into asbestos-related and cell-specific mechanisms of neoplasia, the identification of gene alterations in asbestos-related cancers can help to a better understanding of exposure risk. To understand the aetiology of asbestos-induced malignancies and to increase our knowledge of mesothelial carcinogenesis, we compared genetic...

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PMID: 23435014
DOI: 10.1093/mutage/get008

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EGFR
KRAS

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