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Article

Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer.

International journal of cancer - 21 Apr 1995

Top B, Mooi W J, Klaver S G, Boerrigter L, Wisman P, Elbers H R, Visser S, Rodenhuis S

Abstract excerpt

A series of 54 resected primary non-small-cell lung carcinomas was analyzed for p53 gene mutations and for p53 protein accumulation and the findings were correlated with clinical parameters. Mutations in exons 5 through 8 of the p53 gene were identified by a denaturing gradient gel electrophoresis (DGGE) assay and cycle sequencing, whereas p53 protein accumulation was detected in paraffin-embedded tissue by...

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PMID: 7615358
DOI: 10.1002/ijc.2910640203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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