Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer.

doi:10.1002/ijc.2910640203

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Article

Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer.

International journal of cancer - 21 Apr 1995

Top B, Mooi W J, Klaver S G, Boerrigter L, Wisman P, Elbers H R, Visser S, Rodenhuis S

Abstract excerpt

A series of 54 resected primary non-small-cell lung carcinomas was analyzed for p53 gene mutations and for p53 protein accumulation and the findings were correlated with clinical parameters. Mutations in exons 5 through 8 of the p53 gene were identified by a denaturing gradient gel electrophoresis (DGGE) assay and cycle sequencing, whereas p53 protein accumulation was detected in paraffin-embedded tissue by...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Carcinoma, Non-Small-Cell Lung
Electrophoresis, Polyacrylamide Gel
Exons
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunohistochemistry

Lung Neoplasms

Male

Middle Aged

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 7615358
DOI: 10.1002/ijc.2910640203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7615358-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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