In vitro effects of IL-12 and IL-2 on NK cells, cytokine release and clonogenic activity in myelodysplastic syndromes (MDS).

doi:10.1038/sj.leu.2400813

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Article

In vitro effects of IL-12 and IL-2 on NK cells, cytokine release and clonogenic activity in myelodysplastic syndromes (MDS).

Leukemia - 1 Oct 1997

Sarina B, Cortelezzi A, Cattaneo C, Pomati M, Silvestris I, Di Stefano M, Lambertenghi-Deliliers D, Hu C, Monza M, Maiolo A T

Abstract excerpt

We evaluated the in vitro effects of IL-12, alone and in association with IL-2 on MDS bone marrow and peripheral blood cells. Thirty-six patients and 14 healthy subjects were studied. Natural killer-activity (NK-a) levels and lymphocyte immunophenotypes were determined in fresh bone marrow (BMMNC...

Topics

Adult
Aged
Aged, 80 and over
Bone Marrow
Bone Marrow Cells
Cell Differentiation
Cell Division
Cytokines
Female
Humans
Immunophenotyping
Interleukin-12
Interleukin-2
Killer Cells, Natural
Lymphocytes
Male
Middle Aged
Myelodysplastic Syndromes

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PMID: 9324294
DOI: 10.1038/sj.leu.2400813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9324294-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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