Article
In vitro effects of IL-12 and IL-2 on NK cells, cytokine release and clonogenic activity in myelodysplastic syndromes (MDS).
Leukemia - 1 Oct 1997
Sarina B, Cortelezzi A, Cattaneo C, Pomati M, Silvestris I, Di Stefano M, Lambertenghi-Deliliers D, Hu C, Monza M, Maiolo A T
Abstract excerpt
We evaluated the in vitro effects of IL-12, alone and in association with IL-2 on MDS bone marrow and peripheral blood cells. Thirty-six patients and 14 healthy subjects were studied. Natural killer-activity (NK-a) levels and lymphocyte immunophenotypes were determined in fresh bone marrow (BMMNC) and peripheral blood mononuclear cells (PBMNC), which then were resuspended in medium containing IL-2, IL-12 or IL-2...
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