Article
Phenotypic and functional characteristics of in vivo-induced interleukin-12-activated killer cells.
Immunology letters - 1 Dec 1995
Nishimura T, Watanabe K, Lee U, Yahata T, Kobayashi M, Herrmann S H, Habu S
Abstract excerpt
A single i.p. administration of IL-12 (2000 U/mouse) into the mice caused the elevation of serum IFN-gamma activity and the generation of killer cells which can lyse various kinds of tumor cells including both NK-sensitive and -resistant tumor cells. Such in vivo induced killer cells were not detected in the mice treated with the same dose of IL-2. The generation of IL-12-activated killer cells (IL-12AK) peaked...
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