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Article

Establishment of an IL-12-responsive T cell clone: its characterization and utilization in the quantitation of IL-12 activity.

Journal of leukocyte biology - 1 Mar 1997

Maruo S, Ahn H J, Yu W G, Tomura M, Wysocka M, Yamamoto N, Kobayashi M, Hamaoka T, Trinchieri G, Fuijiwara H

Abstract excerpt

We previously demonstrated that proliferation of terminally differentiated Th1 clones depends primarily on an interleukin-12 (IL-12)-paracrine mechanism mediated by their interactions with antigen-presenting cells (APC) rather than on an IL-2-autocrine mechanism. Such a Th1 clone (4-86, C57BL/6 origin) was cultured with recombinant IL-12 (rIL-12) in the absence of either antigen or APC. Some cells survived for...

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PMID: 9060458
DOI: 10.1002/jlb.61.3.346

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APC

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