Article
Effects of interleukin-12 on in vitro culture with interleukin-2 of regional lymph node lymphocytes from lung cancer patients.
Cancer immunology, immunotherapy : CII - 1 Oct 1996
Hanagiri T, Takenoyama M, Yoshimatsu T, Hirashima C, Yoshino I, Nakanishi K, Nagashima A, Nomoto K, Yasumoto K
Abstract excerpt
In the present study, we carried out a functional analysis of regional lymph node lymphocytes (RLNL) from patients with lung cancer after in vitro activation by interleukin-2 (IL-2) and interleukin-12 (IL-12). IL-12 (100 U/ml) enhanced both the proliferation and cytotoxic activity of RLNL in a culture with low doses of IL-2 (5-10 JRU/ml). After comparing an RLNL culture with a low dose of IL-2 alone, a higher...
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