Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myeloproliferative disease and myelodysplastic syndrome induced by transplantation of bone marrow cells expressing mutant p53.

Leukemia - 1 Oct 1997

Shounan Y, MacKenzie K, Dolnikov A, Miller M, Symonds G

Abstract excerpt

p53 mutations are the most common genetic alterations observed in human cancers including lymphomas and leukemias. We have previously shown that transduction of normal murine hematopoietic cells with mutant p53 alone in vitro results in an enhanced proliferative capacity and modified differentiation potential of transduced cells. In order to investigate further the role of mutant p53 in hematopoietic cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cell Survival
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Mice, Inbred BALB C

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 9324283
DOI: 10.1038/sj.leu.2400782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myeloproliferative disease and myelodysplastic syndrome induced by transplantation of bone marrow cells expressing mutant p53.PMID 9324283Read ↗

Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis.Semantic proximity Read ↗

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humansSemantic proximity Read ↗

Impact of TP53 alteration on allogeneic hematopoietic cell transplantation outcomes for myelodysplastic syndromes.Semantic proximity Read ↗

Retroviral transduction of Philadelphia-positive chronic myeloid leukemia cells with a human mutant p53 cDNA and its effect on in vitro proliferation.Semantic proximity Read ↗

Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.Semantic proximity Read ↗

High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome.Semantic proximity Read ↗

TP53 mutations in myelodysplastic syndrome.Semantic proximity Read ↗

The SKM-1 Leukemic Cell Line Established from a Patient with Progression to Myelomonocytic Leukemia in Myelodysplastic Syndrome (MDS)-Contribution to Better Understanding of MDSSemantic proximity Read ↗

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner.Semantic proximity Read ↗

Dissemination and tissue invasiveness in murine acute leukemia associated with acquisition of p53 mutation and loss of wild-type p53.Semantic proximity Read ↗

Mutant N-ras Induces Myeloproliferative Disorders and Apoptosis in Bone Marrow Repopulated MiceSemantic proximity Read ↗

[P53 genes and malignant hematologic diseases].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.