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Article

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner.

Cell cycle (Georgetown, Tex.) - 1 Jun 2013

Haupt Sue, Mitchell Catherine, Corneille Vincent, Shortt Jake, Fox Stephen, Pandolfi Pier Paolo, Castillo-Martin Mireia, Bonal Dennis M, Cordon-Cardo Carlos, Lozano Guillermina, Haupt Ygal

Abstract excerpt

UNLABELLED: p53 mutations and downregulation of promyelocytic leukemia (PML) are common genetic alterations in human cancers. In healthy cells these two key tumor suppressors exist in a positive regulatory loop, promoting cell death and cellular senescence. However, the influence of their interplay on tumorigenesis has not been explored directly in vivo. The contribution of PML to mutant p53 driven cancer was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23656786
DOI: 10.4161/cc.24805
PMCID: PMC3713131

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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