Article
Retroviral transduction of Philadelphia-positive chronic myeloid leukemia cells with a human mutant p53 cDNA and its effect on in vitro proliferation.
Experimental hematology - 1 Jan 1994
Bi S, Barton C M, Lemoine N R, Cross N C, Goldman J M
Abstract excerpt
Alterations in the tumor suppressor gene p53 are associated with the pathogenesis of blastic transformation of chronic myeloid leukemia (CML), but their exact role, particularly their relationship with the chimeric protein p210BCR/ABL, is poorly defined. Point mutations in p53 have been found in...
Topics
- Cell Division
- Cells, Cultured
- Chimera
- DNA, Neoplasm
- Drug Synergism
- Fusion Proteins, bcr-abl
- Gene Transfer Techniques
- Growth Substances
- Hematopoiesis
- Hematopoietic Stem Cells
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Lymphocyte Activation
- Mutation
- Retroviridae
- Transduction, Genetic
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53