Article
High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2015
Cleven Arjen H G, Nardi Valentina, Ok Chi Young, Goswami Maitrayee, Dal Cin Paola, Zheng Zongli, Iafrate A John, Abdul Hamid Myrurgia A, Wang Sa A, Hasserjian Robert P
Abstract excerpt
Identification of p53-positive cells by immunohistochemistry in bone marrow from primary myelodysplastic syndrome patients correlates with the presence of TP53 mutations and poor prognosis. Mutations in the tumor suppressor gene TP53 are more frequent in therapy-related acute myeloid leukemia and myelodysplastic syndrome than in de novo disease, but the role of p53 immunohistochemistry in the therapy-related...
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