The SKM-1 Leukemic Cell Line Established from a Patient with Progression to Myelomonocytic Leukemia in Myelodysplastic Syndrome (MDS)-Contribution to Better Understanding of MDS

Abstract excerpt

Although molecular and cytogenetic studies strongly point to the role of oncogenes, the mechanisms underlying the development of MDS and their progressive evolution to AML are still largely unknown. It has been postulated that AML has a preleukemic stage and a multi step pathogenesis, with the preleukemic stem cell able to undergo clonal evolution, with the acquisition of karyotypic abnormalities, leading to the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acute Myeloid Leukemia Research
• Share to Cancer-related Molecular Pathways
• Share to Sarcoma Diagnosis and Treatment