Article
Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.
Blood - 1 Jun 1993
Sugimoto K, Hirano N, Toyoshima H, Chiba S, Mano H, Takaku F, Yazaki Y, Hirai H
Abstract excerpt
The p53 gene is currently thought to be a tumor suppressor gene, and its alterations have been suggested to be involved in the pathogenesis of several human malignancies, including some leukemias and lymphomas. We present here evidence for the possible involvement of p53 gene mutations in the mye...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromosome Aberrations
- Chromosome Disorders
- Gene Expression
- Genes, p53
- Genes, ras
- Humans
- Karyotyping
- Leukemia
- Mutation
- Myelodysplastic Syndromes
- RNA, Messenger
- RNA, Neoplasm