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Article

Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.

Blood - 1 Jun 1993

Sugimoto K, Hirano N, Toyoshima H, Chiba S, Mano H, Takaku F, Yazaki Y, Hirai H

Abstract excerpt

The p53 gene is currently thought to be a tumor suppressor gene, and its alterations have been suggested to be involved in the pathogenesis of several human malignancies, including some leukemias and lymphomas. We present here evidence for the possible involvement of p53 gene mutations in the myelodysplastic syndrome (MDS), although the incidence is relatively low. Forty-four patients with MDS and six patients...

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PMID: 8499637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.PMID 8499637Read ↗

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