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Article

Dissemination and tissue invasiveness in murine acute leukemia associated with acquisition of p53 mutation and loss of wild-type p53.

Molecular carcinogenesis - 1 Jun 1995

Hsiao M, Wu C Y, Low J, Pattengale P, Yeargin J, Haas M

Abstract excerpt

Approximately 60% of mice treated with split-dose radiation develop leukemias that disseminate widely through the body, whereas 40% of the treated mice incur leukemias that are contained entirely within the thymus. We studied the status of p53 in non-cultured samples of thymic leukemias and in ce...

Topics

Alleles
Animals
Base Sequence
Cell Division
DNA, Neoplasm
Gene Deletion
Genes, p53
Heterozygote
Immunohistochemistry
Leukemia, Radiation-Induced
Leukemia-Lymphoma, Adult T-Cell
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Neoplasm Invasiveness

Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 7605579
DOI: 10.1002/mc.2940130208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7605579-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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