Article
Myostatin maps to the interval containing the bovine mh locus.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 1997
Smith T P, Lopez-Corrales N L, Kappes S M, Sonstegard T S
Abstract excerpt
Myostatin (GDF-8) is a member of the transforming growth factor-beta superfamily and plays a role in muscle growth and development. Mice having targeted disruption of this gene display marked increases in muscle mass, a phenotype similar to the muscular hypertrophy (mh) in several cattle breeds. Physical mapping data developed from YAC clones indicate the bovine myostatin gene lies close to the centromere of...
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