Article
Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.
Genome research - 1 Sept 1997
Kambadur R, Sharma M, Smith T P, Bass J J
Abstract excerpt
A visibly distinct muscular hypertrophy (mh), commonly known as double muscling, occurs with high frequency in the Belgian Blue and Piedmontese cattle breeds. The autosomal recessive mh locus causing double-muscling condition in these cattle maps to bovine chromosome 2 within the same interval as myostatin, a member of the TGF-beta superfamily of genes. Because targeted disruption of myostatin in mice results in...
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