Article
Fine-mapping and candidate gene analysis of bovine spinal muscular atrophy.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2006
Krebs Stefan, Medugorac Ivica, Russ Ingolf, Ossent Pete, Bleul Ulrich, Schmahl Wolfgang, Förster Martin
Abstract excerpt
Bovine spinal muscular atrophy (SMA), an autosomal recessive neurodegenerative disease, has been mapped at moderate resolution to the distal part of Chromosome 24. In this article we confirm this location and fine-map the SMA locus to an interval of approximately 0.8 cM at the very distal end of BTA24. Despite remarkable similarity to human SMA, the causative gene SMN can be excluded in bovine SMA. However, the...
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