Article
Marker-assisted introgression of the Compact mutant myostatin allele MstnCmpt-dl1Abc into a mouse line with extreme growth effects on body composition and muscularity.
Genetical research - 1 Dec 2004
Bünger Lutz, Ott Gerhard, Varga László, Schlote Werner, Rehfeldt Charlotte, Renne Ulla, Williams John L, Hill William G
Abstract excerpt
Myostatin is a negative regulator of muscle growth and mutations in its gene lead to muscular hypertrophy and reduced fat. In cattle, this is seen in 'double muscled' breeds. We have used marker-assisted introgression to introduce a murine myostatin mutation, MstnCmpt-dl1Abc [Compact (C)], into an inbred line of mice (DUHi) that had been selected on body weight and had exceptional growth. Compared with homozygous...
Topics
- Alleles
- Animals
- Biomarkers
- Body Composition
- Crosses, Genetic
- Female
- Genes, Regulator
- Heterozygote
- Homozygote
- Male
- Mice
- Mice, Inbred Strains
- Muscle, Skeletal
- Organ Size