Article

Myostatin: a modulator of skeletal-muscle stem cells

2005-10-26

Abstract excerpt

Myostatin, or GDF-8 (growth and differentiation factor-8), was first identified through sequence identity with members of the BMP (bone morphogenetic protein)/TGF-β (transforming growth factor-β) superfamily. The skeletal-muscle-specific expression pattern of myostatin suggested a role in muscle development. Mice with a targeted deletion of the myostatin gene exhibit a hypermuscular phenotype. In addition, inactiv...

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Literature Corpus work: 32002198-8738-57af-905b-46efff5d116c
DOI: 10.1042/bst0331513

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