Article
Target genes of myostatin loss-of-function in muscles of late bovine fetuses.
BMC genomics - 1 Mar 2007
Cassar-Malek Isabelle, Passelaigue Florent, Bernard Carine, Léger Jean, Hocquette Jean-François
Abstract excerpt
BACKGROUND: Myostatin, a muscle-specific member of the Transforming Growth Factor beta family, negatively regulates muscle development. Double-muscled (DM) cattle have a loss-of-function mutation in their myostatin gene responsible for the hypermuscular phenotype. Thus, these animals are a good model for understanding the mechanisms underpinning muscular hypertrophy. In order to identify individual genes or...
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