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A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle.

Nature genetics - 1 Sept 1997

Grobet L, Martin L J, Poncelet D, Pirottin D, Brouwers B, Riquet J, Schoeberlein A, Dunner S, Ménissier F, Massabanda J, Fries R, Hanset R, Georges M

Abstract excerpt

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled animals are characterized by an increase in muscle mass of about 20%, due to general skeletal-mus...

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Molecular Sequence Data
Phenotype
Base Sequence
Genotype
Amino Acid Sequence
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Chromosome Mapping

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PMID: 9288100
DOI: 10.1038/ng0997-71

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9288100-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle.PMID 9288100Read ↗

Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.Semantic proximity Read ↗

The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals.Semantic proximity Read ↗

Target genes of myostatin loss-of-function in muscles of late bovine fetuses.Semantic proximity Read ↗

[Positional clonage and characterization of the bovine myostatin gene].Semantic proximity Read ↗

Functional effect of mir-27b on myostatin expression: a relationship in Piedmontese cattle with double-muscled phenotype.Semantic proximity Read ↗

Myostatin maps to the interval containing the bovine mh locus.Semantic proximity Read ↗

Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects.Semantic proximity Read ↗

Genetic variation in the bovine myostatin gene in UK beef cattle: allele frequencies and haplotype analysis in the South Devon.Semantic proximity Read ↗

Discovery of SNPs and indel 11-bp of the myostatin gene and its association with the double-muscled phenotype in Belgian blue crossbred cattle.Semantic proximity Read ↗

Mutations in the myostatin gene leading to hypermuscularity in mammals: indications for a similar mechanism in fish?Semantic proximity Read ↗

Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle.Semantic proximity Read ↗

Marker-assisted introgression of the Compact mutant myostatin allele MstnCmpt-dl1Abc into a mouse line with extreme growth effects on body composition and muscularity.Semantic proximity Read ↗

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