Article
Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome.
Biochemical and biophysical research communications - 29 May 1992
Sasamura H, Hein L, Krieger J E, Pratt R E, Kobilka B K, Dzau V J
Abstract excerpt
We report the existence of two structurally distinct forms of the angiotensin receptor AT-1 in the mouse. A Balb/c mouse genomic library was screened by homology screening with a polymerase chain reaction (PCR) amplified probe. Restriction mapping and sequencing of the isolated genes revealed the presence of two receptor isoforms, here named the mouse AT-1a and AT-1b receptors, containing 22 different amino...
Topics
- Amino Acid Sequence
- Angiotensin II
- Animals
- Base Sequence
- Cloning, Molecular
- Genetic Variation
- Mice
- Molecular Sequence Data
- Multigene Family
- Receptors, Angiotensin
- Sequence Homology, Nucleic Acid