Article
Targeting deletion of angiotensin type 1B receptor gene in the mouse.
The American journal of physiology - 1 Mar 1997
Chen X, Li W, Yoshida H, Tsuchida S, Nishimura H, Takemoto F, Okubo S, Fogo A, Matsusaka T, Ichikawa I
Abstract excerpt
We null mutated the mouse angiotensin type 1B (AT1B) receptor gene (Agtr1b) by gene targeting. To identify the specific cell types carrying high Agtr1b gene transcriptional activities, the AT1B coding exon was replaced with a reporter gene, lacZ. In 6- to 8-wk-old Agtr1b -/- mice, high AT1B trans...
Topics
- Aldosterone
- Animals
- Blood Pressure
- Choroid Plexus
- Exons
- Genes, Reporter
- Genetic Carrier Screening
- Genetic Vectors
- Genotype
- Homozygote
- Lac Operon
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Pituitary Gland, Anterior
- RNA, Messenger
- Receptor, Angiotensin, Type 1