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Article

Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins.

The Journal of cell biology - 30 Jun 2008

Scott Daniel C, Schekman Randy

Abstract excerpt

Misfolded proteins in the endoplasmic reticulum (ER) are identified and degraded by the ER-associated degradation pathway (ERAD), a component of ER quality control. In ERAD, misfolded proteins are removed from the ER by retrotranslocation into the cytosol where they are degraded by the ubiquitin-proteasome system. The identity of the specific protein components responsible for retrotranslocation remains...

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Identifiers

PMID: 18573918
DOI: 10.1083/jcb.200804053
PMCID: PMC2442213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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