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Article

ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7.

BMC cell biology - 6 Dec 2013

Tretter Thomas, Pereira Fábio P, Ulucan Ozlem, Helms Volkhard, Allan Susanne, Kalies Kai-Uwe, Römisch Karin

Abstract excerpt

BACKGROUND: The Sec61 channel mediates protein translocation across the endoplasmic reticulum (ER) membrane during secretory protein biogenesis, and likely also during export of misfolded proteins for ER-associated degradation (ERAD). The mechanisms of channel opening for the different modes of translocation are not understood so far, but the position of the large ER-lumenal loop 7 of Sec61p suggests a decisive...

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Share to Endoplasmic Reticulum
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24314051
DOI: 10.1186/1471-2121-14-56
PMCID: PMC3897919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7.PMID 24314051Read ↗

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