Article
Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae.
Nature - 28 Aug 1997
Tsukamoto Y, Kato J, Ikeda H
Abstract excerpt
DNA double-strand breaks are repaired by homologous recombination or DNA end-joining, but the latter process often causes legitimate recombination and chromosome rearrangements. One of the factors involved in the end-joining process is Hdf1, a yeast homologue of Ku protein. We used the yeast two-hybrid assay to show that Hdf1 interacts with Sir4, which is involved in transcriptional silencing at telomeres and HM...
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