Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast.

Nucleic acids research - 15 Jul 2000

Hegde V, Klein H

Abstract excerpt

Mitotic cells experience double-strand breaks (DSBs) from both exogenous and endogenous sources. Since unrepaired DSBs can result in genome rearrangements or cell death, cells mobilize multiple pathways to repair the DNA damage. In the yeast Saccharomyces cerevisiae, mitotic cells preferentially use a homologous recombination repair pathway. However, when no significant homology to the DSB ends is available,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to DNA, Fungal
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Fungal Proteins

Share to Genes, Regulator

Share to Saccharomyces cerevisiae Proteins

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 10908335
DOI: 10.1093/nar/28.14.2779
PMCID: PMC102644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast.PMID 10908335Read ↗

Srs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.Semantic proximity Read ↗

Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.Semantic proximity Read ↗

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.Semantic proximity Read ↗

Dual role of Arabidopsis SRS2 helicase in meiotic recombinationSemantic proximity Read ↗

Srs2/PARI DNA helicase mediates abscission inhibition in response to chromatin bridges in yeast and human cellsSemantic proximity Read ↗

Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase.Semantic proximity Read ↗

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.Semantic proximity Read ↗

The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles.Semantic proximity Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.Semantic proximity Read ↗

Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.