Article
SMC1 coordinates DNA double-strand break repair pathways.
Nucleic acids research - 1 Jan 2004
Schär Primo, Fäsi Margaret, Jessberger Rolf
Abstract excerpt
The SMC1/SMC3 heterodimer acts in sister chromatid cohesion, and recent data indicate a function in DNA double-strand break repair (DSBR). Since this role of SMC proteins has remained largely elusive, we explored interactions between SMC1 and the homologous recombination (HR) or non-homologous end-joining (NHEJ) pathways for DSBR in Saccharomyces cerevisiae. Analysis of conditional single- and double mutants of...
Topics
- Base Sequence
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- Cisplatin
- Cross-Linking Reagents
- DNA Damage
- DNA Repair
- Molecular Sequence Data
- Mutation
- Radiation, Ionizing
- Recombination, Genetic