Article
Molecular genetic analysis of the yeast repressor Rfx1/Crt1 reveals a novel two-step regulatory mechanism.
Molecular and cellular biology - 1 Sept 2005
Zhang Zhengjian, Reese Joseph C
Abstract excerpt
In Saccharomyces cerevisiae, the repressor Crt1 and the global corepressor Ssn6-Tup1 repress the DNA damage-inducible ribonucleotide reductase (RNR) genes. Initiation of DNA damage signals causes the release of Crt1 and Ssn6-Tup1 from the promoter, coactivator recruitment, and derepression of transcription, indicating that Crt1 plays a crucial role in the switch between gene repression and activation. Here we...
Topics
- Chromatin
- DNA Damage
- DNA-Binding Proteins
- Epistasis, Genetic
- Gene Expression Regulation, Fungal
- Histone Deacetylases
- Mutation
- Nuclear Proteins
- Protein Binding
- Protein Structure, Tertiary
- Repressor Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Structure-Activity Relationship