Article
New p53 mutations in hilar cholangiocarcinoma.
European journal of clinical investigation - 1 Sept 2000
Tullo A, D'Erchia A M, Honda K, Kelly M D, Habib N A, Saccone C, Sbisà E
Abstract excerpt
BACKGROUND: Inactivation of the tumour suppressor gene, p53, is the commonest genetic abnormality in human cancer. The study of the type of p53 mutation in a given tumour may provide prognostic information, clues to aetiology and become useful for therapeutics. MATERIALS AND METHODS: The molecular characterisation of p53 was performed by restriction analysis, denaturing gradient gel electrophoresis, and gene...
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