Article
Mutations of p53 in gallbladder carcinomas in high-incidence areas of Japan and Chile.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 1998
Yokoyama N, Hitomi J, Watanabe H, Ajioka Y, Pruyas M, Serra I, Shirai Y, Hatakeyama K
Abstract excerpt
Gallbladder adenocarcinomas from patients in two high-prevalence areas, Niigata (Japan) and Santiago (Chile), were analyzed for acquired mutations in exons 5-8 of the p53 tumor suppressor gene, and the characteristics of p53 alterations in the two groups were compared. Of 42 tumors, 22 (52.4%) ha...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma
- Chile
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Gallbladder Neoplasms
- Humans
- Immunohistochemistry
- Incidence
- Japan
- Male
- Middle Aged
- Mutation
- Tumor Suppressor Protein p53