Article
Analysis of the p53 tumor-suppressor gene in hepatocellular carcinomas from Britain.
Hepatology (Baltimore, Md.) - 1 Dec 1992
Challen C, Lunec J, Warren W, Collier J, Bassendine M F
Abstract excerpt
Human hepatocellular carcinomas from patients in Britain, an area of low prevalence of hepatocellular carcinoma and low dietary exposure to aflatoxin B1, were analyzed for mutations in the p53 tumor-suppressor gene. Abnormalities in the p53 gene were detected in 2 of 19 hepatocellular carcinomas...
Topics
- Base Sequence
- Carcinoma, Hepatocellular
- Codon
- Exons
- Female
- Genes, p53
- Humans
- Liver Neoplasms
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sequence Deletion
- United Kingdom