Nitrosated peptides and polyamines as endogenous mutagens in O6-alkylguanine-DNA alkyltransferase deficient cells.

doi:10.1093/carcin/18.8.1561

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Article

Nitrosated peptides and polyamines as endogenous mutagens in O6-alkylguanine-DNA alkyltransferase deficient cells.

Carcinogenesis - 1 Aug 1997

Sedgwick B

Abstract excerpt

Mutants of Escherichia coli and Saccharomyces cerevisiae that lack O6-alkylguanine-DNA alkyltransferase activities have increased spontaneous mutation rates, indicating the presence of a cellular metabolite that can alkylate DNA. Bacterially catalysed nitrosation has been implicated previously in...

Topics

Azaserine
Cadaverine
Dose-Response Relationship, Drug
Escherichia coli
Humans
Methylnitronitrosoguanidine
Methyltransferases
Mutation
O(6)-Methylguanine-DNA Methyltransferase
Polyamines
Putrescine
Spermine

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