Article
Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA.
Nucleic acids research - 15 Apr 1999
Kooistra R, Zonneveld J B, Watson A J, Margison G P, Lohman P H, Pastink A
Abstract excerpt
The protein O 6-alkylguanine-DNA alkyltransferase(alkyltransferase) is involved in the repair of O 6-alkylguanine and O 4-alkylthymine in DNA and plays an important role in most organisms in attenuating the cytotoxic and mutagenic effects of certain classes of alkylating agents. A genomic clone encompassing the Drosophila melanogaster alkyltransferase gene ( DmAGT ) was identified on the basis of sequence...
Topics
- Amino Acid Sequence
- Animals
- Bacterial Proteins
- Base Sequence
- Cloning, Molecular
- DNA Repair
- DNA, Complementary
- Drosophila melanogaster
- Enzyme Inhibitors
- Escherichia coli
- Escherichia coli Proteins
- Gene Deletion
- Guanine
- Humans