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Article

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase.

Journal of bacteriology - 1 Mar 1991

Rebeck G W, Samson L

Abstract excerpt

Escherichia coli expresses two DNA repair methyltransferases (MTases) that repair the mutagenic O6-methylguanine (O6MeG) and O4-methylthymine (O4MeT) DNA lesions; one is the product of the inducible ada gene, and here we confirm that the other is the product of the constitutive ogt gene. We have generated various ogt disruption mutants. Double mutants (ada ogt) do not express any O6MeG/O4MeT DNA MTases,...

Topics

Alkylation
Chromosome Mapping
Cloning, Molecular
DNA Repair
Escherichia coli
Genes, Bacterial
Methylnitronitrosoguanidine
Methyltransferases
Mutagenesis
Mutation
O(6)-Methylguanine-DNA Methyltransferase

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Identifiers

PMID: 2002008
DOI: 10.1128/jb.173.6.2068-2076.1991
PMCID: PMC207742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2002008-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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