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Article

X-ray induction of O6-alkylguanine-DNA alkyltransferase protects against some of the biological effects of N-methyl-N'-nitro-N-nitrosoguanidine in C3H 10T1/2 cells.

Radiation research - 1 Aug 1991

von Hofe E, Kennedy A R

Abstract excerpt

We have shown previously that the repair of O6-methylguanine can be induced in murine fibroblasts (C3H 10T1/2 cells) by exposure to X rays. The magnitude of the response is less, however, than is observed in the well-characterized adaptive response of various prokaryotes to methylating agents. To determine whether the induction of O6-alkylguanine-DNA alkyltransferase in C3H 10T1/2 cells is sufficient for...

Topics

Animals
Carmustine
Cell Survival
Cell Transformation, Neoplastic
Cells, Cultured
DNA Damage
Enzyme Induction
Methylnitronitrosoguanidine
Methyltransferases
Mice
Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

O(6)-Methylguanine-DNA Methyltransferase

X-Rays

Source

Identifiers

PMID: 1947007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1947007-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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