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Article

Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli.

Journal of bacteriology - 1 Sept 1996

Taverna P, Sedgwick B

Abstract excerpt

Escherichia coli ada ogt mutants, which are totally deficient in O6-methylguanine-DNA methyltransferases, have an increased spontaneous mutation rate. This phenotype is particularly evident in starving cells and suggests the generation of an endogenous DNA alkylating agent under this growth condition. We have found that in wild-type cells, the level of the inducible Ada protein is 20-fold higher in...

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Identifiers

PMID: 8752326
DOI: 10.1128/jb.178.17.5105-5111.1996
PMCID: PMC178305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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