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Article

DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli.

Journal of bacteriology - 1 Jun 1994

Mackay W J, Han S, Samson L D

Abstract excerpt

The Escherichia coli Ada and Ogt DNA methyltransferases (MTases) are known to transfer simple alkyl groups from O6-alkylguanine and O4-alkylthymine, directly restoring these alkylated DNA lesions to guanine and thymine. In addition to being exquisitely sensitive to the mutagenic effects of methylating agents, E. coli ada ogt null mutants display a higher spontaneous mutation rate than the wild type. Here, we...

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Identifiers

PMID: 8195077
DOI: 10.1128/jb.176.11.3224-3230.1994
PMCID: PMC205492

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Source receipt: pubmed, retrieved 7 Sept 2026.

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