DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli.

doi:10.1128/jb.176.11.3224-3230.1994

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Article

DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli.

Journal of bacteriology - 1 Jun 1994

Mackay W J, Han S, Samson L D

Abstract excerpt

The Escherichia coli Ada and Ogt DNA methyltransferases (MTases) are known to transfer simple alkyl groups from O6-alkylguanine and O4-alkylthymine, directly restoring these alkylated DNA lesions to guanine and thymine. In addition to being exquisitely sensitive to the mutagenic effects of methyl...

Topics

Alkylating Agents
Alkylation
Bacterial Proteins
Cell Division
DNA Modification Methylases
DNA Repair
Escherichia coli
Escherichia coli Proteins
Lac Operon
Methyltransferases
Mutation
O(6)-Methylguanine-DNA Methyltransferase
Transcription Factors

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