Article
Skin abnormality in aged fyn-/- fak+/- mice.
Carcinogenesis - 1 Aug 1997
Ilić D, Kanazawa S, Nishizumi H, Aizawa S, Kuroki T, Mori S, Yamamoto T
Abstract excerpt
Focal adhesion kinase (FAK) is a novel non-receptor protein tyrosine kinase implicated in transducing signals from cell surface receptors. Its association with Fyn, a member of the Src family of tyrosine kinases, has been observed in cell lines. To examine in vivo the interaction between these two proteins, Fyn-deficient mice were bred with fak heterozygous mutants (Fak deficiency is embryonic lethal). A majority...
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